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KMID : 0357919750090020137
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Korean Journal of Pathology
1975 Volume.9 No. 2 p.137 ~ p.144
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The Changes of Myocardial Mitochondria Induced by Carbon Monoxide Poisoning
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서인수/In Soo Suh
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Abstract
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It was well known that carbon monoxide induced significant derangements of various
parameters of cardiac functions. Recently, Adams et al. reported considerablly decreased
myocardial oxygen consumption which suggested deranged function of myocardial
mitochondria. In order to observe the morphologic changes of the myocardial myocardria,
ten rabbits were exposured to the carbon monoxide: Three animals were exposured to
0.2％ CO gas for 2 hours: Three were exposured to 0.2％ for 4 hours: Four were
exposures to 0.1％ for 2 hours daily for 5 days.
Results obtained were summarized as follow:
Mitochondria of myocardial fiber showed marked degenerative changes. Cristae were
fragmented and decreased in number with partial disruption. Numerous electron dense
granules were occurred in the site of cristae disruption. Mitochondria were fused
together to form large irregular shaped body, chondriosphere of de Robertis. No
significant changes were noted in the nuclei, myofilament and intercalated disc in all of
the experimental groups. Sarcoplasmic reticuluml is markedly dilated and glycogen
particles and lipid droplets were slightly decreased.
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